Goal-oriented treatment and combination therapy for pulmonary arterial hypertension
نویسندگان
چکیده
منابع مشابه
Goal-oriented treatment and combination therapy for pulmonary arterial hypertension.
Combination therapy may improve outcome in patients with severe pulmonary arterial hypertension (PAH). PAH patients were treated according to a goal-oriented therapeutic strategy. Patients who did not reach the treatment goals with monotherapy received combination treatment according to a predefined strategy, including bosentan, sildenafil and inhaled iloprost. Intravenous iloprost and lung tra...
متن کاملRepeated Assessment of Exercise Capacity under Goal-Oriented Sequential Combination Therapy for Pulmonary Arterial Hypertension
Little is known about the effects of sequential combination therapy on exercise capacity in pulmonary arterial hypertension (PAH). We monitored exercise capacity by cardiopulmonary exercise testing (CPX) and observed the benefit of using a peak oxygen uptake (VO2) cut-off of 15 mL/min/kg to guide combination therapy. The patients underwent CPX at baseline and after 3, 6, and 12 months. In patie...
متن کاملCirculatory power and ventilatory power over time under goal-oriented sequential combination therapy for pulmonary arterial hypertension
Many therapeutic options are available for patients with pulmonary arterial hypertension (PAH). However, little is known about the effects of sequential combination therapy on exercise capacity. Here we monitored exercise capacity by cardiopulmonary exercise testing (CPX) and observed the benefit of using a peak VO2 cutoff of 15 mL/kg/min to guide combination therapy. Thirty patients newly diag...
متن کاملGoal-oriented therapy in paediatric pulmonary arterial hypertension: are we ready?
Pulmonary arterial hypertension (PAH) is still a fatal disease, affecting patients of all ages including children [1]. In the last 20 years, significant progress has been achieved in the understanding of the disease, and in particular, in the medical approach, with the introduction of new therapies. Goal-oriented strategy represents a significant progress in PAH management and has emerged as th...
متن کاملCombination therapy in pulmonary arterial hypertension: a meta-analysis.
OBJECTIVES It is unclear whether combination therapy is efficient and well tolerated in patients with pulmonary arterial hypertension (PAH). The objective was to analyze completed trials assessing the efficacy and safety of treating PAH with combination therapy. METHODS We performed a meta-analysis of all randomized controlled combination therapy trials that evaluated efficacy and safety in P...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2005
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.05.00075305